Zafirlukast inhibits complexation of Lsr 2 with DNA and growth of Mycobacterium
نویسندگان
چکیده
Abbreviations used: DMSO, Dimethyl sulfoxide; E. coli, Escherichia coli; FP, 15 Fluorescence Polarization; LB, Luria-Bertani; MDR-TB, Multi-Drug Resistant 16 Tuberculosis; MALDI, Matrix-Assisted Laser Desorption/Ionization; MIC, 17 Minimum Inhibitory Concentration; M. smegmatis, Mycobacterium smegmatis; 18 Mtb, Mycobacterium tuberculosis; MTT, (3-(4,5-Dimethylthiazol-2-yl)-2,519 diphenyltetrazolium bromide, NCC, National Institutes of Health Clinical 20 Collection; PCR, Polymerase Chain Reaction; RT-PCR, Reverse Transcription 21 Copyright © 2013, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.02407-12 AAC Accepts, published online ahead of print on 25 February 2013
منابع مشابه
Zafirlukast inhibits complexation of Lsr2 with DNA and growth of Mycobacterium tuberculosis.
The mycobacterial nucleoid-associated protein Lsr2 is a DNA-bridging protein that plays a role in condensation and structural organization of the genome and acts as a global repressor of gene transcription. Here we describe experiments demonstrating that zafirlukast inhibits the complexation between Lsr2 and DNA in vitro. Zafirlukast is shown to inhibit growth in two different species of mycoba...
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